Sodium selenate
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چکیده
Human toxicity Elemental selenium metal has a relatively low order of toxicity. Acute poisoning with selenium and its salts are rare, however, in excessive amount toxic and even fatal action was documented. Normal whole blood selenium levels in adults range from 0.085 to 0.13 mg/l [2]. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption, although specific information on the possible dermal absorption of sodium selenate was not found. Sodium selenate is the least toxic inorganic selenium form; sodium selenite (Na2SeO3) is more toxic [3]. Several toxic symptoms are listed here [1]: cardiovascular: ECG changes indicating myocardial damage; hypotension; in severe cases – fatal cardiac arrest; respiratory: pulmonary edema, respiratory tract irritation, cough, and respiratory failure; neurologic: CNS depression, convulsions (at acute selenium poisoning), dizziness, irritability, restlessness, headache, and coma; gastrointestinal: nausea, vomiting, salivation, and gastrointestinal pain.
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Selenium compounds like selenite and selenate have strong inhibitory effects, particularly on mammalian tumor cell growth by unknown mechanisms. We found that the addition of sodium selenite and sodium selenate inhibited the growth of human 3B6 and BL41 lymphocytes. Selenite was more potent because 10 microM selenite produced a growth inhibitory effect similar to that of 250 microM selenate. Th...
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Sodium selenite and sodium selenate are approved inorganic Se (selenium) compounds in human and animal nutrition serving as precursors for selenoprotein synthesis. In recent years, numerous additional biological effects over and above their functions in selenoproteins have been reported. For greater insight into these effects, our present study examined the influence of selenite and selenate on...
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Consumption of Se accumulator plants by livestock can result in Se intoxication. Recent research indicates that the Se forms most common in Se accumulator plants are selenate and Se-methylselenocysteine (MeSeCys). In this study the absorption, distribution, and elimination kinetics of Se in serum and whole blood of lambs dosed with a single oral dose of (1, 2, 3, or 4 mg Se/kg BW) of sodium sel...
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Selenium is known to be present in the bile of selenium-treated animais. Smith et al. (I) reported that rabbit bile, after acute and subacute poisoning with sodium selenite and selenate (0.5 to 3 mg. of selenium per kilo), contained smaller amounts of selenium (36 to 48 y per cent) after oral treatment than after intravenous treatment (336 y per cent). In studies by Dudley (2), it was found, af...
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